Available Technologies

Molecular Biology

• High-throughput method for producing monoclonal antibodies
• Method for isolation of CPG methylated DNA
• Cell-based method for analysis of protein-protein interactions  

Protein Expression

• Systematic approach for generating soluble protein variants

Research Tools

• Medaka EST clones 

Targets

• Novel biomarkers for detection of testicular carcinoma in situ and derived cancers in human samples
• Aurora-A kinase  

Services

• Monoclonal antibody service
• Transgenic mouse service

Instruments

• Phasing macromolecular structures by UV-induced damage
• Fast response mini stage temperature controller
• Microscope incubator box and control device

University Clinics Heidelberg

• Technology offers

Software
» go to software download page

 

• C3D: Image Analysis Library for automated crystal alignment on X-ray beamlines
• Agadir
• ARP/wARP 7.0
• ChipSkipper
• Dali (MaxSprout)
• FOLD-X
• Gene2disease
• GeneSkipper
• InterPreTs Interaction Prediction through Structure
• Medusa
• PolyPhen
• ATSAS - software for small angle scattering data analysis from biological macromolecules
• SMART
• SmartCell
• SNPeffect
• STRING
• TANGO 

Animal Models

• Mice carrying homozygous disruptions in the GLIS2 gene
• Mice carrying brain-specific loss of Profilin 2
• Mice carrying floxed P38 alpha cassette
• BSX Knock-out mice
• Mice lacking CNS specific NEMO or IKK2 activation of NF-kappaB
• IKK2 Knock-out mice
• Knock-out mice lacking the 42kDa C/EBPalpha translational isoform
• C/EBPalpha-dPHR and C/EBPalpha-TTS knock-in mice
• Mice carrying point mutations on specific docking sites of TrkB receptors
• Mice carrying NEMO deletion in gut epithelial cells 
• Brain-specific N-cofilin inactivation in mice
• Mice carrying keratinocyte specific IKK1 ablations
• Mice overexpressing IGF-1 in keratinocytes show improved wound healing and accelerated hair follicle formation and cycling
• GFP-p65 knock-in mice as a tool to study NF-kappaB dynamics in vivo
• Medaka fish carrying macrophage specific fluorescent markers